We are looking for collaboration in two scientific directions presented at our department:

1. Pharmacochemical and pharmacognostic analysis of medicinal plants of Southern Ukraine with further study of their anti-inflammatory, antibacterial, and wound-healing activities for the treatment of inflammatory diseases of various organs and systems

2. Molecular genetic methods of forecasting and evaluating the effectiveness and safety of treatment of a number of socially important diseases, such as tuberculosis and viral hepatitis C.

Current: The current research activity is dedicated to the relationship

between genetic polymorphism of human liver enzymes (CYP2C9,

CYP2C19, CYP2E1, CYP3A4, N-acetyltransferase 2) and tuberculosis

treatment outcome, drug-resistance development. Prospective: we are

ready to participate in genotyping of Ukrainians regarding local genetic

polymorphism and its association with different pathological state

development and treatment effectiveness, for instance an association with

biotransformation polymorphism and effectiveness of immunosuppressive

treatment.

Current: Another direction of our research activity is about preclinical

studies of new compounds – coordinated compounds of metallic salts with

natural bioligands, aminomethane sulfonic acid etc. Prospective: we can

conduct preclinical studies (acute/chronic toxicity; specific neurotropic

About the Institution

The Department of Pharmacology and Pharmacognosy is one of the leading departments of this profile in Ukraine. It was at the department of pharmacology and pharmacognosy of Odesa National Medical University that the field of clinical pharmacology was launched for the first time in Ukraine.

Among the priority scientific directions of the Department of Pharmacology and Pharmacognosy is the research of a unique class of biologically active substances with membrane-protective activity based on a complex of metals and various bioligands of metabolite origin, the creation and research of drugs with anti-inflammatory and reparative, immunomodulatory and antiviral action based on plant raw materials of Southern Ukraine. According to the results of research, a new dosage form of the drug "Marepolimiel" with pronounced anti-inflammatory and reparative properties was developed and implemented, the first atypical tranquilizer "Litonit" was developed and implemented, patented in a number of countries (USA, Japan), a number of drugs were developed (Nicomag, Tuftsin, etc. .).

In addition, one of the directions of scientific activity of the department is the study of medicinal plants of the South of Ukraine with the aim of creating modern phytoremedies based on them for the treatment of current diseases. In particular, in cooperation with scientists of the National Pharmaceutical University (Kharkiv), an extract of slanky anchovies with prostatoprotective action was developed and the spectrum of its pharmacological activity is currently being studied. The antimicrobial, anti-inflammatory and immunotropic effect of this extract is studied in the conditions of various models of experimental prostatitis in rats.

Modern biophysical and molecular genetic methods of forecasting and evaluating the effectiveness and safety of treatment of a number of socially important diseases such as tuberculosis and viral hepatitis C are also being introduced into clinical practice.

Fortunately, our university as a whole and our department were not damaged by the war.

Research Focus / Keywords

Search, selection and research of new biologically active substances of plant origin with further study of their pharmacological activity, primarily anti-inflammatory and antibacterial, antifungal Molecular genetic methods of forecasting and evaluating the effectiveness of the safety of treatment of tuberculosis and hepatitis C. Key words: natural compounds, medicinal plants, antibacterial activity, PCR, drug resistance, genetic polymorphism, tuberculosis, hepatitis C